Conference Proceeding

Synthesis of some novel 1,3,4-Thiadiazole derivatives as possible anticancer agents

Dr. B. Gowramma ,
Assistant professor, J. S. S. College of Pharmacy, India

Dr. B. Gowramma has completed her Doctor of Philosophy in Pharmacy from JSS College of Pharmacy, Ooty, Tamilnadu. Later she worked as an analytical chemist in Drug testing laboratory, J. S. S. College of Pharmacy, Rocklands, Ooty, Tamilnadu. Presently she is working as an Assistant professor in the Department of Pharmaceutical Chemistry, J. S. S. College of Pharmacy, Rocklands, Ooty, Tamilnadu, India.

Objective: The objective of the study was to synthesize series of 2-[bis(2-hydroxyethyl)amino]-N'-[5-substituted phenyl)-1,3,4-thiadiazol-2-yl]acetohydrazide and evaluated for their possible in vitro and in vivo anticancer activity against DLA cell line.
Method: 2-[bis(2-chloroethyl) amino]-N'-[5-substituted phenyl)-1,3,4-thiadiazol-2-yl]acetohydrazide have been synthesized by chlorination of 2-[bis(2-hydroxyethyl)amino]-N'-[5-substituted phenyl)-1,3,4-thiadiazol-2-yl] acetohydrazide with phosphorous oxychloride and phosphorous pentachloride (7a-7f).
Results: The synthesis of the targeted compounds was (7a-f) confirmed through their MP, IR, 1H-NMR and mass spectrum studies. Compounds 7a and 7d showed considerable anticancer activity against DLA cell line for the invitro and in vivo studies.
Conclusion: It may be concluded that the presence of nitro and chloro phenyl substituted 1,3,4-thiadiazoles showed significant anticancer activity.

Published: 11 May 2017