Conference Proceeding

Restoration of metabolic rhythms attenuates diabetes and obesity-induced cardiometabolic disorders

Dr. Girish C. Melkani

The diabetes and obesity epidemic is associated with a number of metabolic diseases, including elevated risk for cardiovascular disease (CVD), insulin resistance in cardiac and skeletal muscle and diabetes. Chronic disruption of circadian clock by erratic eating pattern or sleep deprivation can increase predisposition to obesity and metabolic diseases. Therefore, interventions that improve molecular circadian and metabolic rhythms are potential entry points for prevention and prognosis of cardiometabolic diseases. Taking advantage of the short lifespan and extensive genetic tools available in the Drosophila melanogaster (fruit fly) model, we have recently shownthat imposing a daily rhythm of eating and fasting by time-restricted feeding (TRF) attenuates age-related or high fat diet inducedcardiac dysfunction(Gill et al. Science, 2015). TRF does not trigger a gene expression signature of caloric restriction and its metabolic benefits require an intact circadian clock. To test whether circadian eating pattern can alleviate some of the genetic obesity-induced comorbidities, we subject young Drosophila to TRF.Obese mutant flies showed age-dependent deterioration of cardiac and skeletalmuscle performance followed by increase triglycerides level and compromised insulin sensitivity. They also exhibitsleep perturbation similar to that in humans.Interestingly, obese flies under TRF showed attenuated obesity-induced cardiac and skeletal muscle senescence, possibly by decreasing lipid accumulation, increased insulin sensitivity and by maintaining metabolic homeostasis due to improved sleep.Our findings are potentially applicable to human health such as in community-based approaches to improve cardiovascular and other health matrix outcomes linked with slowing or preventing obesity-induced cardiac disorders and other comorbidities.

Published: 17 October 2017


Copyright: © 2017 Dr. Girish C. Melkani. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.