Conference Proceeding

Regenerative Medicine and Cell Based Therapy: The Future of Organ Transplant

Dr. Pradeep Mahajan,
Stem Rx Bio Science Solutions Pvt Ltd, Rabale, Navi Mumbai, India

Organ replacement is gradually becoming commonplace in modern medicine. Despite technological advances, shortage of donors and bioethical issues concerning transplantation has continually been a cause of concern. Additionally, immune-suppression in the individual is of paramount importance that determines success of the procedure. Regenerative medicine/Cell based therapy has shown tremendous potential in augmenting organ function as well as repair and regeneration of damaged organs. Furthermore, this promising field can be explored to address the current needs of organ transplantation namely inexhaustible source of tissues and immune-suppression free transplantation. Stem cells are capable of differentiation into diverse populations of specialized cell types. Along with the properties of self-renewal and anti-inflammation, these cells are also potent immune-modulatory agents. In context of organ transplantation, the major advantage of mesenchymal stem cells (MSCs) is that they escape immune recognition and can inhibit immune responses. Additionally, MSCs have immune-regulatory effects on T-regulatory (CD4+/25high Foxp3 +) cells, B cells, NK cells and dendritic cells. MSCs exert species specific immune-modulation. Direct cell-cell contact and paracrine mechanisms have been described as the mechanisms by which mesenchymal stem cells (MSCs) exert their immune-modulatory role. The existing dogma of organ transplantation is being challenged by the advent of regenerative medicine. Mesenchymal stem cells present with unexplored properties in transplantation immunobiology and can contribute significantly towards evolution of newer therapeutic avenues in organ replacement.

Published: 27 April 2017