Conference Proceeding

Moringa Oleifera L and its anticancer fractions

Dr. Praveen T.K.,
Assistant Professor, JSS College of Pharmacy, India

Dr. Praveen T.K., is currently working as Assistant Professor, Dept. of Pharmacology, JSS College of Pharmacy, Ooty. He has completed his Bachelor of Pharmacy and Masters of Pharmacy (Pharmacology) from Visveswarapura Institute of Pharmaceutical Sciences, Bangalore. He received his doctoral degree in Pharmaceutical Sciences from The Tamil Nadu Dr. M.G.R. Medical University, Chennai. His research carrier started as a Research Associate/Study Director-Toxicology, R&D Center, The Himalaya Herbal Health Care, Bangalore, India.

The n-hexane, chloroform, ethyl acetate, methanol extracts of the M. oleifera leaves and 15 fractions (F1 to F15) of ethyl acetate extract were evaluated for their in vitro and in vivo anticancer activity using Hep-2 cell lines and Dalton’s lymphoma as cites model in mice, respectively. Among the tested samples, the F1 fraction showed potential cytotoxic effect in Hep-2 cell lines with a CTC50 value of 12.5 ± 0.5 µg/ml. In vivo studies with the doses 5 and 10 mg/kg, p.o. demonstrated significant reduction in body weight and increased mean survival time compared to the control group. These results were also comparable to the standard, 5-Fluorouracil, treated animals. We have also successfully isolated and characterized the anticancer fraction, F1 from the leaves of M. oleifera L.

Published: 11 May 2017