Conference Proceeding

Metabolic Syndrome (MS): Perils of pregnancy and precursor of childhood

Dr. Shailini Singh

Pregnancy associated with maternal MS is a challenge to manage. Metabolic Syndrome comprises of visceral and/or truncal obesity, hyperlipidemia, hypertension, coronary artery disease (CAD) and Insulin resistance (IR). Insulin resistance can present itself with varied severity as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), gestational diabetes (GDM) and finally developing overt Type 2 diabetes mellitus (T2DM). In 2008 global Summit IDF president declared “there is global Pandemic of diabetes mellitus in the new millennium that is a threat to cardiovascular health and world economy”. He gave some stunning statistics that in 2025 without any intervention it’s predicted that there will be 800 million T2DM, which is 15% of the world population. There are ethnic variations in diabetes in women. Compared to western population, Asians develop diabetes at younger ages, at lower degree of obesity and at much higher rates, given the same amount of weight gain. Asians have less muscle mass that leads to increased propensity for insulin resistance compared to western population. This “metabolically obese” phenotype among normal weight individuals may explain the increased predisposition for diabetes despite relatively low prevalence of truncal obesity. We have data that indicates that Asians have beta cell defect. The prepregnancy maternal obesity is an independent risk factor than weight gains during pregnancy. The larger the weights gain higher the birth weight (BW). Maternal obesity is also associated with gestational hypertension and pre eclampsia, also IGT, GDM leading to shoulder dystocia and cesarean delivery. In the offspring it increased the risk of congenital malformation. HAPO trial showed that maternal blood sugars below the cut offs for GDM still increases perinatal morbidity and childhood obesity. Management of these requires a team approach and will be discussed.

Published: 17 October 2017


Copyright: © 2017 Dr. Shailini Singh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.