Conference Proceeding

Intracerebroventricular injection of Streptozotocin promotes increase in body temperature: implications for Alzheimer’s disease.

Robson Cristiano Lillo Vizin

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that promotes the decline of cognitive abilities and noncognitive symptoms that include alteration of body temperature (Tb). AD is well accepted to be a multifactorial disease, since it is related to a combination of genetic and environmental factors, in which anesthesia-induced hypothermia is suggested as a risk factor. Also, AD can be classified as early-onset familial (FAD) or late-onset sporadic (SAD), where the latter corresponds to 99% of cases. Intracerebroventricularstreptozotocin (icv-STZ) injection has been used as an important model to study SAD. However, there is no information about the effect of icv-STZ injection on the thermoregulatory system and the effect of isoflurane-induced hypothermia in this model. The aim of this study was to evaluate the effect of the icv-STZ injection in low-dose and isoflurane-induced hypothermia in Tb of rats.

Published: 17 October 2017


Copyright: © 2017 Robson Cristiano Lillo Vizin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.