Conference Proceeding

Creating organs using nature own scaffolding matrix and human stem cells

Dr. Suchitra S-Holgersson,
Department of Transplantation Surgery, Sahlgrenska Academy at the Gothenburg University, Sweden

Different pathological conditions such as congenital organ absence, severe organ injuries, end-stage organ failure and malignancy-related organ removal, have few effective therapeutic options apart from a whole organ transplant, that, however, often meets with a serious shortage of suitable donor organs. To solve these clinical issues we are developing a novel tissue engineering approach with a multi-disciplinary team of highly qualified and experienced clinicians, stem cell and molecular biologists, biotechnologists, materials and surface scientists. A recent strategy in tissue/organ engineering, is the procedure of decellularizing a whole donor organ to obtain a complex 3D-biomatrix-scaffold maintaining the intrinsic vascular network, that is subsequently recellularized with recipient's autologous organ-specific differentiated cells or/and stem cells, to build a potentially functional biological substitute. Such a strategy has been clinically used by us in pioneering studies to replace blood vessels in patients with portal vein thrombosis. In another approach, we are also using naturally-derived matrices or even natural/polymer-composite materials to produce 3D-printed scaffolds for either cell-free or autologous cell-seeded tissue engineering procedures. The strategic goal is to facilitate dissemination, transfer and translation of knowledge from research findings into potentially improved clinical therapeutics through policies, interventions, services and products.

Published: 27 April 2017