Conference Proceeding

Bioactive Metabolites of Okinawan Cyanobacteria

Dr. Daisuke Uemura,
Obesity is a growing health problem in modern society because it is a risk factor for many lifestyle-related diseases, including diabetes and cardiovascular disorders. Thus, studies on anti-obesity are expected to contribute to the prevention and treatment of various diseases. To propose promising drug candidates, we tried to identify the natural product which controls fatty acid metabolism and explication of those mechanisms. Yoshinone A, a ?-pyrone containing-natural product derived from a cyanobacterium Leptolyngbya sp. collected in Ishigaki Island, was first identified as an inhibitor of fat cell differentiation of 3T3-L1 cells1,2. We examined the effect of yoshinone A to adiposities and found that the compound decreased the triglyceride level in the cells. Furthermore, administration of yoshinone A derivative to mice with high fat-diet clearly demonstrated that the compound inhibited weight increase in vivo. These findings suggested that yoshinone A might be a potent drug lead to treat obesity. And then, I will present some new topics.

Published: 28 July 2017


Copyright: © 2017 Daisuke Uemura. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.